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Its mechanism involves multiple pathways that contribute to weight loss: Appetite regulation : Semaglutide acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing hunger and increasing feelings of satiety Gastric emptying : It slows the rate at which food leaves the stomach, prolonging fullness after meals Glucose regulation : It enhances insulin secretion in a glucose-dependent manner and suppresses inappropriate glucagon release The slowed gastric emptying associated with Wegovy is a primary contributor to the nausea many patients experience, particularly during dose escalation

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